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Cajun Chicken Alfredo Baked Ziti

Cajun Chicken Alfredo Baked Ziti brings creamy Parmesan richness together with smoky, peppery heat for a comforting pasta bake. Tender, spice-rubbed chicken mingles with sautéed bell peppers, onions, and juicy tomatoes beneath a blanket of melted mozzarella. It’s a cozy weeknight dinner or potluck favorite that balances creamy Alfredo with bold Cajun flair.

  • Prep20 mins
  • Cook40 mins
  • Serves8
  • DifficultyMedium
Cajun Chicken Alfredo Baked Ziti
  1. 1

    Preheat the oven to 400 degrees F (200 degrees C).

  2. 2

    Bring a large pot of lightly salted water to a boil. Cook the ziti in the boiling water, stirring occasionally, until slightly firm, about 10 minutes. Drain.

  3. 3

    While the ziti cooks, heat olive oil in a large skillet over medium to medium-high heat. Add the chicken, Cajun seasoning, and salt. Cook, stirring, until the chicken is cooked through and starting to brown, about 10 minutes. Add the bell peppers, onion, and 1/2 of the garlic; cook until tender, 5 to 7 minutes. Add the tomatoes and bring to a simmer.

  4. 4

    Meanwhile, melt the butter in a medium saucepan over medium heat. Add the remaining garlic and cook until fragrant, about 1 minute. Add the flour; cook and stir for 1 minute. Slowly whisk in the milk and bring to a gentle boil. Stir in Parmesan cheese, salt, and pepper. Add more Parmesan to thicken or more milk to thin to your preference.

  5. 5

    Add the cooked ziti to the chicken mixture; toss to coat. Transfer to a deep casserole dish. Pour the cheese sauce over the pasta mixture and top with mozzarella cheese.

  6. 6

    Bake in the preheated oven until the top is golden and bubbly, about 15 minutes.

About This Recipe

Cajun Chicken Alfredo Baked Ziti is a Cajun and Creole dinner recipe made with 16 ingredients. It takes about 1 hr, serves 8, and is rated medium. Key ingredients include All Purpose Flour, Butter, Cajun Seasoning, and Chicken Breast. Each serving provides about 641.88 kcal, and is a good source of protein.

Recipe Questions

What is Cajun Chicken Alfredo Baked Ziti?
It is a Cajun and Creole recipe made with 16 ingredients, usually served for dinner or lunch.
What is Cajun Chicken Alfredo Baked Ziti made of?
The main ingredients are All-Purpose Flour, Butter, Cajun Seasoning, Chicken Breast, Garlic. The full list of 16 is above.
What goes well with Cajun Chicken Alfredo Baked Ziti?
Explore these Cajun and Creole side-dish recipes.
How long does it take to make Cajun Chicken Alfredo Baked Ziti?
About 1 hr in total: 20 mins to prepare and 40 mins to cook.
How many calories are in one serving?
One serving provides about 641.88 kcal. The full nutrition breakdown is above.
Is Cajun Chicken Alfredo Baked Ziti easy to make?
This recipe is rated medium, with 16 ingredients and 6 steps.

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