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Creamy Chicken Alfredo Bake

Creamy Chicken Alfredo Bake layers tender chicken and penne in a rich, garlicky Alfredo sauce, finished with a bubbling blend of mozzarella and Cheddar. It’s comforting and cheesy with a silky texture and a hint of onion and garlic warmth. Perfect for cozy weeknights or potlucks when you want something hearty and crowd-pleasing.

  • Prep15 mins
  • Cook45 mins
  • Serves6
  • DifficultyEasy
Creamy Chicken Alfredo Bake
  1. 1

    Preheat the oven to 350 degrees F (175 degrees C).

  2. 2

    Put the chicken in a pot and cover it with water. Bring to a boil over high heat; lower the heat and simmer until the centers are no longer pink and the juices run clear, about 15 minutes.

  3. 3

    Meanwhile, bring a large pot of lightly salted water to a boil. Add the penne and cook, stirring occasionally, until tender yet slightly firm, about 11 minutes. Drain.

  4. 4

    Drain the cooked chicken and cut it into bite-size pieces.

  5. 5

    Combine the chicken, noodles, Alfredo sauce, 1/2 of the mozzarella cheese, milk, onion powder, and garlic powder in a large bowl and mix well.

  6. 6

    Pour the mixture into a 1 1/2-quart casserole dish. Layer the remaining mozzarella cheese and the Cheddar cheese on top.

  7. 7

    Bake in the preheated oven until melted and bubbly, about 25 minutes.